Hi Andrew,
I have consciously moved away from audio a bit, not that I don't use my system, I do every day, but I don't spend a lot of time sitting and listening to music and I have strayed away from these forums, it was consuming too much of me.
Not sure where that came from, but I will try to address your question(s). Let me say up front that I have very little experience with tube gear, but as I believe I posted above, I can understand everyones affection with tubes after owning the 2275, but for me I did (do) not miss the tubes once I switched to the Mac combo. The key in that statement is, "for me". I have a friend that is very much a tube guy and he really likes the 2275; I had him over once again after I purchased the 402 and was using the 2275 as a preamp and he prefered the 2275 by itself, I did not. He has yet to make it over to hear my system with the C46.
While I was very pleased with the 2275, the 402/46 works best for me and this includes sonically.
The setup you suggest, with 2 MC275's and the C2200 I will speculate would sound wonderful, the MC275's are very well reported, but I don't see that as an avenue for me; if I wanted to stay with tubes I would keep my 2275. That said, if I was looking to purchase a tube amp, the 275 would be at the top of my list.
As already mentioned, I am pleased, very pleased, with the Mac gear, this includes looks, function and sound. With that in mind, and not spending much time here, hopefully I can finally settle down in regards to my stereo.