I own these and also have them in a fairly large room.

I vary on my set-up but have found that whether I am using an Ayre integrated or a Bryston amp the sound is terrific. Curiously, the changes that are most impactful are with the speaker cables I use. I rotate Nordost Heimdalls with Acoustic Zen Satoris and have come to love each, but very different, sound.

Finally, I also added a sub (Snell) and used the directions given in a PS Audio newsletter to set it up. That addition stopped my quest for better sound.

Enjoy those Cremonas.