Recently changed the MF A300 for the A5. More drive with the bigger output of the A5. Also have just added the Wadia 170i and Audio Note DAC to the combination and enjoy the flexibility of the iPod interface.
A move of house has changed the sound somewhat, with hard floors and highly reflective surfaces, so may look at damping the room in the future.
System is used for music, tv, movies rather than dedicated audio. I have a couple of other small systems I use for my "get away from it all" music listening (see bedroom systm photo). If synergy is what it's all about, then I'm very pleased with my current set up. The MF front end and amplification blend nicely with the Mordaunt-Short speakers (review posted a few weeks ago).
There is upgrade potential for the future but I'm happy for the moment and just enjoying the music.
If you have some extra cash try the Itouch. The solid state drive produces no mechanical noise unlike the iPod classic further improving the sound. Plus all the other features on it are pretty damn cool.